Article
Phenotypes of dnaXE145A Mutant Cells Indicate that the Escherichia coli Clamp Loader Has a Role in the Restart of Stalled Replication Forks.
Journal of bacteriology - 15 Dec 2017
Flåtten Ingvild, Helgesen Emily, Pedersen Ida Benedikte, Waldminghaus Torsten, Rothe Christiane, Taipale Riikka, Johnsen Line, Skarstad Kirsten
Abstract excerpt
The Escherichia colidnaXE145A mutation was discovered in connection with a screen for multicopy suppressors of the temperature-sensitive topoisomerase IV mutation parE10 The gene for the clamp loader subunits τ and γ, dnaX, but not the mutant dnaXE145A , was found to suppress parE10(Ts) when overexpressed. Purified mutant protein was found to be functional in vitro, and few phenotypes were found in vivo apart...
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