Article
UV-induced DNA damage disrupts the coordination between replication initiation, elongation and completion.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Feb 2021
Wendel Brian M, Hollingsworth Suzanne, Courcelle Charmain T, Courcelle Justin
Abstract excerpt
Replication initiation, elongation and completion are tightly coordinated to ensure that all sequences replicate precisely once each generation. UV-induced DNA damage disrupts replication and delays elongation, which may compromise this coordination leading to genome instability and cell death. Here, we profiled the Escherichia coli genome as it recovers from UV irradiation to determine how these replicational...
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