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Article

Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells.

The Journal of biological chemistry - 20 Jun 2003

Cornish Ann L, Chong Mark M, Davey Gayle M, Darwiche Rima, Nicola Nicos A, Hilton Douglas J, Kay Thomas W, Starr Robyn, Alexander Warren S

Abstract excerpt

Suppressor of cytokine signaling-1 (SOCS-1) is an essential regulator of cytokine signaling. SOCS-1-/- mice die before weaning with a complex disease characterized by fatty degeneration and necrosis of the liver. This disease is mediated by interferon (IFN) gamma as neonatal mortality fails to occur in SOCS-1-/-IFNgamma-/- mice. However, the immune system of healthy SOCS-1-/-IFNgamma-/- mice is dysregulated with...

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Identifiers

PMID: 12665516
DOI: 10.1074/jbc.M303021200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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