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Article

SOCS, inflammation, and cancer

5 Apr 2013

Abstract excerpt

Signal transduction pathways elicited by cytokines and hormones have been shown to regulate distinct stages of development. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of cytokine signaling mediated by the JAK-STAT signaling pathway. In particular, SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and...

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Identifiers

PMID: 24069550
DOI: 10.4161/jkst.24053

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