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Article

SOCS1: a potent and multifaceted regulator of cytokines and cell‐mediated inflammation

14 Dec 2005

Abstract excerpt

Suppressor of cytokine signalling-1 (SOCS1), as the name implies, is a protein that functions as a negative regulator of cytokine signalling. Initially characterized for its ability to inhibit JAK phosphorylation and function, SOCS1 also targets proteins for degradation by the proteosome machinery. The expression of SOCS1 can be regulated at the transcription, translation and protein level. Despite the broad...

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PMID: 16451196
DOI: 10.1111/j.1399-0039.2005.00532.x

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