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Article

SOCS: negative regulators of cytokine signaling for immune tolerance

19 Aug 2021

Abstract excerpt

Cytokines are important intercellular communication tools for immunity. Many cytokines promote gene transcription and proliferation through the JAK/STAT (Janus kinase/signal transducers and activators of transcription) and the Ras/ERK (GDP/GTP-binding rat sarcoma protein/extracellular signal-regulated kinase) pathways, and these signaling pathways are tightly regulated. The SOCS (suppressor of cytokine signaling)...

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PMID: 34415326
DOI: 10.1093/intimm/dxab055

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