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Article

SOCS signaling in autoimmune diseases: Molecular mechanisms and therapeutic implications

5 Mar 2014

Abstract excerpt

Suppressor of cytokine signaling (SOCS) proteins are mainly induced by various cytokines and have been described as classical inhibitors of cytokine signaling. SOCS signaling is involved in the regulation of immune cells, and recent findings suggest that SOCS proteins, especially SOCS1 and SOCS3, are often dysregulated in a wide variety of autoimmune diseases, including systemic lupus erythematosus, rheumatoid...

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PMID: 24595859
DOI: 10.1002/eji.201344369

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