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Article

Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene.

Molecular and cellular biology - 1 Mar 2005

Nguyen Thi T, Cho Kyucheol, Stratton Sabrina A, Barton Michelle Craig

Abstract excerpt

We performed chromatin immunoprecipitation (ChIP) analyses of developmentally staged solid tissues isolated from wild-type and p53-null mice to determine specific histone N-terminal modifications, histone-modifying proteins, and transcription factor interactions at the developmental repressor region (-850) and core promoter of the hepatic tumor marker alpha-fetoprotein (AFP) gene. Both repression of AFP during...

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Source

Open in PubMed Open full text

Identifiers

PMID: 15743813
DOI: 10.1128/MCB.25.6.2147-2157.2005
PMCID: PMC1061614

Genes

AFP
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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