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Article

p53-Mediated Repression of Alpha-Fetoprotein Gene Expression by Specific DNA Binding

1 Feb 1999

Abstract excerpt

Aberrant expression of the alpha-fetoprotein (AFP) gene is characteristic of a majority of hepatocellular carcinoma cases and serves as a diagnostic tumor-specific marker. By dissecting regulatory mechanisms through electromobility gel shift, transient-transfection, Western blot, and in vitro transcription analyses, we find that AFP gene expression is controlled in part by mutually exclusive binding of two...

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Identifiers

PMID: 9891062
DOI: 10.1128/mcb.19.2.1279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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p53-Mediated Repression of Alpha-Fetoprotein Gene Expression by Specific DNA BindingPMID 9891062Read ↗

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