Article
Relationship between DNA methylation, histone H4 acetylation and gene expression in the mouse imprinted Igf2-H19 domain.
FEBS letters - 19 Jan 2001
Grandjean V, O'Neill L, Sado T, Turner B, Ferguson-Smith A
Abstract excerpt
DNA methylation and histone H4 acetylation play a role in gene regulation by modulating the structure of the chromatin. Recently, these two epigenetic modifications have dynamically and physically been linked. Evidence suggests that both modifications are involved in regulating imprinted genes -...
Topics
- Acetylation
- Alleles
- Animals
- Chromatin
- DNA Methylation
- Female
- Fibroblasts
- Gene Expression Regulation
- Gene Silencing
- Genomic Imprinting
- Histone Deacetylase Inhibitors
- Histone Deacetylases
- Histones
- Hydroxamic Acids
- Insulin-Like Growth Factor II
- Male
- Mice
- Precipitin Tests