Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Individual Mouse α-Fetoprotein Enhancer Elements Exhibit Different Patterns of Tissue-Specific and Hepatic Position-Dependent Activities

1 Sept 1995

Abstract excerpt

Transcription of the mouse alpha-fetoprotein (AFP) gene, which is expressed at high levels in the visceral endoderm of the yolk sac and fetal liver and at low levels in the fetal gut, is regulated by three distinct upstream enhancer regions. To investigate the activities of these regions, each enhancer was individually linked to a heterologous human beta-globin promoter fused to the mouse class I H-2Dd structural...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Folate and B Vitamins Research
Share to Hemoglobinopathies and Related Disorders
Share to Pediatric Hepatobiliary Diseases and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7544436
DOI: 10.1128/mcb.15.9.4947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Individual Mouse α-Fetoprotein Enhancer Elements Exhibit Different Patterns of Tissue-Specific and Hepatic Position-Dependent ActivitiesPMID 7544436Read ↗

Mouse alpha-fetoprotein gene 5' regulatory elements are required for postnatal regulation by raf and Rif.Semantic proximity Read ↗

Chicken ovalbumin upstream promoter-transcription factor, hepatocyte nuclear factor 3, and CCAAT/enhancer binding protein control the far-upstream enhancer of the rat alpha-fetoprotein gene.Semantic proximity Read ↗

A position-dependent silencer plays a major role in repressing alpha-fetoprotein expression in human hepatoma.Semantic proximity Read ↗

The mouse fetoprotein transcription factor (FTF) gene promoter is regulated by three GATA elements with tandem E box and Nkx motifs, and FTF in turn activates the Hnf3beta, Hnf4alpha, and Hnf1alpha gene promoters.Semantic proximity Read ↗

High-level activation by a duodenum-specific enhancer requires functional GATA binding sites.Semantic proximity Read ↗

Expression of HNF4alpha isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3' end splicing.Semantic proximity Read ↗

Identification of an enhancer and an alternative promoter in the first intron of the alpha-fetoprotein gene.Semantic proximity Read ↗

Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene.Semantic proximity Read ↗

Quantitative gene expression profiling reveals a fetal hepatic phenotype of murine ES-derived hepatocytes.Semantic proximity Read ↗

Targeted insertion of an IRES Cre into the Hnf4alpha locus: Cre-mediated recombination in the liver, kidney, and gut epithelium.Semantic proximity Read ↗

Pdx-1 is required for activation in vivo from a duodenum-specific enhancer.Semantic proximity Read ↗

In vitro and in vivo comparative study of chimeric liver-specific promotersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.