Article
Mouse alpha-fetoprotein gene 5' regulatory elements are required for postnatal regulation by raf and Rif.
Molecular and cellular biology - 1 Oct 1994
Spear B T
Abstract excerpt
The mouse alpha-fetoprotein (AFP) gene is expressed at high levels in the yolk sac and fetal liver and at low levels in the fetal gut. AFP synthesis decreases dramatically shortly after birth to low levels that are maintained in the adult liver and gut. AFP expression can be reactivated in the adult liver upon renewed cell proliferation such as during liver regeneration or in hepatocellular carcinomas....
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