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Article

p53-Targeted LSD1 Functions in Repression of Chromatin Structure and Transcription In Vivo

24 Jun 2008

Abstract excerpt

Despite years of study focused on the tumor suppressor p53, little is understood about its functions in normal, differentiated cells. We found that p53 directly interacts with lysine-specific demethylase 1 (LSD1) to alter chromatin structure and confer developmental repression of the tumor marker alpha-fetoprotein (AFP). Chromatin immunoprecipitation (ChIP) and sequential ChIP of developmentally staged liver...

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PMID: 18573881
DOI: 10.1128/mcb.00287-08

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