Article
ZBTB20 is a sequence-specific transcriptional repressor of alpha-fetoprotein gene.
Scientific reports - 15 Jul 2015
Zhang Hai, Cao Dongmei, Zhou Luting, Zhang Ye, Guo Xiaoqin, Li Hui, Chen Yuxia, Spear Brett T, Wu Jia-Wei, Xie Zhifang, Zhang Weiping J
Abstract excerpt
Alpha-fetoprotein (AFP) represents a classical model system to study developmental gene regulation in mammalian cells. We previously reported that liver ZBTB20 is developmentally regulated and plays a central role in AFP postnatal repression. Here we show that ZBTB20 is a sequence-specific transcriptional repressor of AFP. By ELISA-based DNA-protein binding assay and conventional gel shift assay, we successfully...
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