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Hereditary persistence of α-fetoprotein and <i>H19</i> expression in liver of BALB/cJ mice is due to a retrovirus insertion in the <i>Zhx2</i> gene

30 Dec 2004

Abstract excerpt

The alpha-fetoprotein (AFP) and H19 genes are transcribed at high levels in the mammalian fetal liver but are rapidly repressed postnatally. This repression in the liver is controlled, at least in part, by the Afr1 gene. Afr1 was defined >25 years ago when BALB/cJ mice were found to have 5- to 20-fold higher adult serum AFP levels compared with all other mouse strains; subsequent studies showed that this...

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PMID: 15626755
DOI: 10.1073/pnas.0408555102

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Hereditary persistence of α-fetoprotein and <i>H19</i> expression in liver of BALB/cJ mice is due to a retrovirus insertion in the <i>Zhx2</i> genePMID 15626755Read ↗

Characterization of the ETnII-alpha endogenous retroviral element in the BALB/cJ Zhx2 ( Afr1 ) allele.Semantic proximity Read ↗

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Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liverSemantic proximity Read ↗

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