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Article

Stimulation of the alpha-fetoprotein promoter by unliganded thyroid hormone receptor in association with protein deacetylation.

Molecular and cellular endocrinology - 25 Feb 2002

Van Reeth Thierry, Gabant Philippe, Szpirer Claude, Szpirer Josiane

Abstract excerpt

alpha-Fetoprotein (AFP) is a serum protein expressed during fetal life, the expression of which is shut off after birth. The activity of the mouse Afp gene promoter region comprised between -80 and -38 bp is regulated by the thyroid hormone receptor (T3R): negatively in the presence of T3 and positively in the absence of T3. The stimulating effect of unliganded T3R is, unexpectedly, antagonized by cofactors that...

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Source

Identifiers

PMID: 11911950
DOI: 10.1016/s0303-7207(01)00739-0

Genes

AFP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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