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Article

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

eLife - 10 Sept 2014

Alpern Daniil, Langer Diana, Ballester Benoit, Le Gras Stephanie, Romier Christophe, Mengus Gabrielle, Davidson Irwin

Abstract excerpt

The functions of the TAF subunits of mammalian TFIID in physiological processes remain poorly characterised. In this study, we describe a novel function of TAFs in directing genomic occupancy of a transcriptional activator. Using liver-specific inactivation in mice, we show that the TAF4 subunit of TFIID is required for post-natal hepatocyte maturation. TAF4 promotes pre-initiation complex (PIC) formation at...

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Source

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Identifiers

PMID: 25209997
DOI: 10.7554/eLife.03613
PMCID: PMC4359380

Genes

TAF4
TAF12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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