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Article

A position-dependent silencer plays a major role in repressing alpha-fetoprotein expression in human hepatoma.

1 Dec 1991

Abstract excerpt

A large percentage of human hepatomas produce alpha-fetoprotein (AFP), but the levels of AFP expression vary greatly among hepatomas. To understand the molecular basis for this variation, we analyzed transcriptional regulatory activities associated with the 5'-flanking region of the AFP gene in two human hepatoma cell lines, HuH-7 and huH-1/cl-2, which produce a high and a low level of AFP, respectively. We found...

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PMID: 1719374
DOI: 10.1128/mcb.11.12.5885

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