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Article

Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver

31 Jul 2008

Abstract excerpt

The alpha-fetoprotein (AFP) gene is highly activated in fetal liver but is dramatically repressed shortly after birth. The mechanisms that underlie AFP transcriptional repression in postpartum liver are not well understood. AFP enhancer, repressor region, and promoter are implicated to be involved in AFP postnatal repression, but the major transcriptional repressor remains undefined. We previously identified a...

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PMID: 18669658
DOI: 10.1073/pnas.0800647105

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