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Article

Genetic dissection of DNA damage tolerance in Bacillus subtilis: RecA and recombination functions regulate translesion synthesis.

Nucleic acids research - 3 Jul 2026

Torres Rubén, Alonso Juan C

Abstract excerpt

Mutagenesis is a fundamental, yet poorly understood, source of genetic variation that underpins microbial evolution and adaptation. When the Bacillus subtilis replicative DNA polymerase (DNAP) PolC encounters DNA lesions induced by endogenous or exogenous insults, it stalls and disassembles. If error-free DNA damage tolerance (DDT) sub-pathways fail to circumvent the lesion, bipartite translesion synthesis (TLS)...

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Identifiers

PMID: 42406627
DOI: 10.1093/nar/gkag673
PMCID: PMC13335488

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DDT

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