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Article

DNA polymerase V activity is autoregulated by a novel intrinsic DNA-dependent ATPase.

eLife - 24 Apr 2014

Erdem Aysen L, Jaszczur Malgorzata, Bertram Jeffrey G, Woodgate Roger, Cox Michael M, Goodman Myron F

Abstract excerpt

Escherichia coli DNA polymerase V (pol V), a heterotrimeric complex composed of UmuD'2C, is marginally active. ATP and RecA play essential roles in the activation of pol V for DNA synthesis including translesion synthesis (TLS). We have established three features of the roles of ATP and RecA. (1) RecA-activated DNA polymerase V (pol V Mut), is a DNA-dependent ATPase; (2) bound ATP is required for DNA synthesis;...

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Identifiers

PMID: 24843026
DOI: 10.7554/eLife.02384
PMCID: PMC4001326

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Source receipt: pubmed, retrieved 7 Sept 2026.

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