Article
The SOS Error-Prone DNA Polymerase V Mutasome and β-Sliding Clamp Acting in Concert on Undamaged DNA and during Translesion Synthesis.
Cells - 1 May 2021
Sikand Adhirath, Jaszczur Malgorzata, Bloom Linda B, Woodgate Roger, Cox Michael M, Goodman Myron F
Abstract excerpt
In the mid 1970s, Miroslav Radman and Evelyn Witkin proposed that Escherichia coli must encode a specialized error-prone DNA polymerase (pol) to account for the 100-fold increase in mutations accompanying induction of the SOS regulon. By the late 1980s, genetic studies showed that SOS mutagenesis required the presence of two "UV mutagenesis" genes, umuC and umuD, along with recA. Guided by the genetics, decades...
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