Article
RecFOR proteins are essential for Pol V-mediated translesion synthesis and mutagenesis.
The EMBO journal - 13 Dec 2006
Fujii Shingo, Isogawa Asako, Fuchs Robert P
Abstract excerpt
When the replication fork moves through the template DNA containing lesions, daughter-strand gaps are formed opposite lesion sites. These gaps are subsequently filled-in either by translesion synthesis (TLS) or by homologous recombination. RecA filaments formed within these gaps are key intermediates for both of the gap-filling pathways. For instance, Pol V, the major lesion bypass polymerase in Escherichia coli,...
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