Article
A RecA protein surface required for activation of DNA polymerase V.
PLoS genetics - 1 Mar 2015
Gruber Angela J, Erdem Aysen L, Sabat Grzegorz, Karata Kiyonobu, Jaszczur Malgorzata M, Vo Dan D, Olsen Tayla M, Woodgate Roger, Goodman Myron F, Cox Michael M
Abstract excerpt
DNA polymerase V (pol V) of Escherichia coli is a translesion DNA polymerase responsible for most of the mutagenesis observed during the SOS response. Pol V is activated by transfer of a RecA subunit from the 3'-proximal end of a RecA nucleoprotein filament to form a functional complex called DNA polymerase V Mutasome (pol V Mut). We identify a RecA surface, defined by residues 112-117, that either directly...
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