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Article

A defect in homologous recombination leads to increased translesion synthesis in E. coli.

Nucleic acids research - 19 Sept 2016

Naiman Karel, Pagès Vincent, Fuchs Robert P

Abstract excerpt

DNA damage tolerance pathways allow cells to duplicate their genomes despite the presence of replication blocking lesions. Cells possess two major tolerance strategies, namely translesion synthesis (TLS) and homology directed gap repair (HDGR). TLS pathways involve specialized DNA polymerases that are able to synthesize past DNA lesions with an intrinsic risk of causing point mutations. In contrast, HDGR pathways...

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Identifiers

PMID: 27257075
DOI: 10.1093/nar/gkw488
PMCID: PMC5027485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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