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Article

Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways.

Blood - 15 Jun 2005

Tong Wei, Zhang Jing, Lodish Harvey F

Abstract excerpt

Erythropoietin (Epo), along with its receptor EpoR, is the principal regulator of red cell development. Upon Epo addition, the EpoR signaling through the Janus kinase 2 (JAK2) activates multiple pathways including Stat5, phosphoinositide-3 kinase (PI-3K)/Akt, and p42/44 mitogen-activated protein kinase (MAPK). The adaptor protein Lnk is implicated in cytokine receptor signaling. Here, we showed that Lnk-deficient...

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Share to Erythroid Precursor Cells
Share to Erythropoiesis
Share to Erythropoietin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Milk Proteins

Share to Mitogen-Activated Protein Kinase 3

Share to Receptors, Erythropoietin

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Source

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Identifiers

PMID: 15705783
DOI: 10.1182/blood-2004-10-4093
PMCID: PMC1894992

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways.PMID 15705783Read ↗

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The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Semantic proximity Read ↗

Adaptor protein Lnk associates with Tyr(568) in c-Kit.Semantic proximity Read ↗

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