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Article

Lnk deficiency partially mitigates hematopoietic stem cell aging.

Aging cell - 1 Dec 2012

Bersenev Alexey, Rozenova Krasimira, Balcerek Joanna, Jiang Jing, Wu Chao, Tong Wei

Abstract excerpt

Upon aging, the number of hematopoietic stem cells (HSCs) in the bone marrow increases while their repopulation potential declines. Moreover, aged HSCs exhibit lineage bias in reconstitution experiments with an inclination toward myeloid at the expense of lymphoid potential. The adaptor protein Lnk is an important negative regulator of HSC homeostasis, as Lnk deficiency is associated with a 10-fold increase in...

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Identifiers

PMID: 22812478
DOI: 10.1111/j.1474-9726.2012.00862.x
PMCID: PMC3500428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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