Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms.

doi:10.1182/blood-2009-12-256768

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Article

Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms.

Blood - 23 Dec 2010

Baran-Marszak Fanny, Magdoud Hajer, Desterke Christophe, Alvarado Anabell, Roger Claudine, Harel Stéphanie, Mazoyer Elizabeth, Cassinat Bruno, Chevret Sylvie, Tonetti Carole, Giraudier Stéphane, Fenaux Pierre, Cymbalista Florence, Varin-Blank Nadine, Le Bousse-Kerdilès Marie-Caroline, Kiladjian Jean-Jacques, Velazquez Laura

Abstract excerpt

Activating mutations in signaling molecules, such as JAK2-V617F, have been associated with myeloproliferative neoplasms (MPNs). Mice lacking the inhibitory adaptor protein Lnk display deregulation of thrombopoietin/thrombopoietin receptor signaling pathways and exhibit similar myeloproliferative characteristics to those found in MPN patients, suggesting a role for Lnk in the molecular pathogenesis of these...

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Identifiers

PMID: 20870899
DOI: 10.1182/blood-2009-12-256768

Genes

JAK2
TPO

Variants

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Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms.PMID 20870899Read ↗

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