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Article

Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2.

The Journal of clinical investigation - 1 Aug 2008

Bersenev Alexey, Wu Chao, Balcerek Joanna, Tong Wei

Abstract excerpt

In addition to its role in megakaryocyte production, signaling initiated by thrombopoietin (TPO) activation of its receptor, myeloproliferative leukemia virus protooncogene (c-Mpl, or Mpl), controls HSC homeostasis and self-renewal. Under steady-state conditions, mice lacking the inhibitory adaptor protein Lnk harbor an expanded HSC pool with enhanced self-renewal. We found that HSCs from Lnk-/- mice have an...

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Source

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Identifiers

PMID: 18618018
DOI: 10.1172/JCI35808
PMCID: PMC2447929

Genes

JAK2
TPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2.PMID 18618018Read ↗

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Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis.Semantic proximity Read ↗

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LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.Semantic proximity Read ↗

Loss of Function Mouse Models Reveal a Novel Regulatory Function for ULK1 in Myeloproliferative Neoplasms.Semantic proximity Read ↗

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