Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lnk constrains myeloproliferative diseases in mice.

The Journal of clinical investigation - 1 Jun 2010

Bersenev Alexey, Wu Chao, Balcerek Joanna, Jing Jiang, Kundu Mondira, Blobel Gerd A, Chikwava Kudakwashe R, Tong Wei

Abstract excerpt

Hematopoietic stem and progenitor cell (HSPC) expansion is regulated by intrinsic signaling pathways activated by cytokines. The intracellular kinase JAK2 plays an essential role in cytokine signaling, and activating mutations in JAK2 are found in a number of hematologic malignancies. We previously demonstrated that lymphocyte adaptor protein (Lnk, also known as Sh2b3) binds JAK2 and attenuates its activity,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokines
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Mice, Knockout

Share to Myeloproliferative Disorders

Share to Phosphotransferases

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 20458146
DOI: 10.1172/JCI42032
PMCID: PMC2877957

Genes

JAK2
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lnk constrains myeloproliferative diseases in mice.PMID 20458146Read ↗

Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2.Semantic proximity Read ↗

Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617FSemantic proximity Read ↗

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasmsSemantic proximity Read ↗

Lnk deficiency partially mitigates hematopoietic stem cell aging.Semantic proximity Read ↗

Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms.Semantic proximity Read ↗

Expression of the adaptor protein Lnk in leukemia cells.Semantic proximity Read ↗

The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Semantic proximity Read ↗

LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.Semantic proximity Read ↗

Loss of Function Mouse Models Reveal a Novel Regulatory Function for ULK1 in Myeloproliferative Neoplasms.Semantic proximity Read ↗

Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.Semantic proximity Read ↗

Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders.Semantic proximity Read ↗

The role of LNK/SH2B3 genetic alterations in myeloproliferative neoplasms and other hematological disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.