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Article

Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis.

The Journal of experimental medicine - 6 Sept 2004

Tong Wei, Lodish Harvey F

Abstract excerpt

Thrombopoietin (Tpo) is the primary cytokine regulating megakaryocyte development and platelet production. Tpo signaling through its receptor, c-mpl, activates multiple pathways including signal transducer and activator of transcription (STAT)3, STAT5, phosphoinositide 3-kinase-Akt, and p42/44 mitogen-activated protein kinase (MAPK). The adaptor protein Lnk is implicated in cytokine receptor and immunoreceptor...

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Share to Megakaryocytes
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Receptors, Cytokine

Share to Receptors, Thrombopoietin

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Source

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Identifiers

PMID: 15337790
DOI: 10.1084/jem.20040762
PMCID: PMC2212736

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis.PMID 15337790Read ↗

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Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2.Semantic proximity Read ↗

Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders.Semantic proximity Read ↗

Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways.Semantic proximity Read ↗

Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617FSemantic proximity Read ↗

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferationSemantic proximity Read ↗

Lnk constrains myeloproliferative diseases in mice.Semantic proximity Read ↗

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-MplSemantic proximity Read ↗

Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease.Semantic proximity Read ↗

Thrombopoietin signal transduction: studies from cell lines and primary cells.Semantic proximity Read ↗

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasmsSemantic proximity Read ↗

The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasmSemantic proximity Read ↗

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