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Article

Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F

17 Mar 2009

Abstract excerpt

The JAK2 mutation JAK2V617F is found frequently in patients with myeloproliferative disorders (MPD) and transforms hematopoietic cells to cytokine-independent proliferation when expressed with specific cytokine receptors. The Src homology 2 (SH2) and pleckstrin homology (PH) domain-containing adaptor protein Lnk (SH2B3) is a negative regulator of hematopoietic cytokine signaling. Here, we show that Lnk is a...

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Identifiers

PMID: 19293402
DOI: 10.1189/jlb.0908575

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Research trail→

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Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617FPMID 19293402Read ↗

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Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders.Semantic proximity Read ↗

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Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursors.Semantic proximity Read ↗

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