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Article

The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.

Molecular and cellular biology - 1 Jun 2005

Drissen Roy, von Lindern Marieke, Kolbus Andrea, Driegen Siska, Steinlein Peter, Beug Hartmut, Grosveld Frank, Philipsen Sjaak

Abstract excerpt

Development of red blood cells requires the correct regulation of cellular processes including changes in cell morphology, globin expression and heme synthesis. Transcription factors such as erythroid Kruppel-like factor EKLF (Klf1) play a critical role in erythropoiesis. Mice lacking EKLF die ar...

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Identifiers

PMID: 15923635
DOI: 10.1128/MCB.25.12.5205-5214.2005
PMCID: PMC1140573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15923635-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.PMID 15923635Read ↗

The multifunctional role of EKLF/KLF1 during erythropoiesis.Semantic proximity Read ↗

Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf.Semantic proximity Read ↗

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivoSemantic proximity Read ↗

Loss of LKLF function results in embryonic lethality in mice.Semantic proximity Read ↗

Novel role for EKLF in megakaryocyte lineage commitmentSemantic proximity Read ↗

Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.Semantic proximity Read ↗

EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleationSemantic proximity Read ↗

Krüppel-Like Factor 1: A Pivotal Gene Regulator in ErythropoiesisSemantic proximity Read ↗

Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development.Semantic proximity Read ↗

GPS2 promotes erythroid differentiation by control of the stability of EKLF proteinSemantic proximity Read ↗

Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region.Semantic proximity Read ↗

Erythroid Krüppel-Like Factor (KLF1): A Surprisingly Versatile Regulator of Erythroid Differentiation.Semantic proximity Read ↗

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