Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LNK mutations and myeloproliferative disorders.

American journal of hematology - 1 Feb 2016

McMullin Mary Frances, Cario Holger

Abstract excerpt

The lymphocyte adaptor protein (LNK) is one of a family of adaptor proteins involved cell signaling and control of B cell populations. It has a critical role in regulation of signaling in hematopoiesis. Lnk negatively regulates cytokine initiated cell signaling and it functions as a negative regulator of the mutant protein in myeloproliferative neoplasms JAK2V617F. A number of mutations in LNK have been described...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cells
Share to Adaptor Proteins, Signal Transducing
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Janus Kinase 2

Share to Myeloproliferative Disorders

Share to Polycythemia

Share to Proteins

Source

Identifiers

PMID: 26660394
DOI: 10.1002/ajh.24259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LNK mutations and myeloproliferative disorders.PMID 26660394Read ↗

[Role of LNK gene mutation in pathogenesis of myeloproliferative neoplasms-review].Semantic proximity Read ↗

The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Semantic proximity Read ↗

The role of LNK/SH2B3 genetic alterations in myeloproliferative neoplasms and other hematological disorders.Semantic proximity Read ↗

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasmsSemantic proximity Read ↗

Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms.Semantic proximity Read ↗

LNK mutations in JAK2 mutation-negative erythrocytosis.Semantic proximity Read ↗

Lnk constrains myeloproliferative diseases in mice.Semantic proximity Read ↗

Possible new LNK mutations in myeloproliferative neoplasms.Semantic proximity Read ↗

The Polymorphisms in LNK Gene Correlated to the Clinical Type of Myeloproliferative Neoplasms.Semantic proximity Read ↗

Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617FSemantic proximity Read ↗

Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders.Semantic proximity Read ↗

LNK can also be mutated outside PH and SH2 domains in myeloproliferative neoplasms with and without V617FJAK2 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.