Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adaptor protein Lnk associates with Tyr(568) in c-Kit.

The Biochemical journal - 15 Oct 2008

Gueller Saskia, Gery Sigal, Nowak Verena, Liu Liqin, Serve Hubert, Koeffler H Phillip

Abstract excerpt

The adaptor protein Lnk is expressed in haemopoietic cells and plays a critical role in haemopoiesis. Animal model studies demonstrated that Lnk acts as a broad inhibitor of signalling pathways in haemopoietic lineages. Lnk belongs to a family of proteins sharing several structural motifs, including an SH2 (Src homology 2) domain which binds phosphotyrosine residues in various signal-transducing proteins. The SH2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Phosphorylation

Share to Proteins

Share to Proto-Oncogene Proteins c-kit

Share to src Homology Domains

Share to Tyrosine

Source

Identifiers

PMID: 18588518
DOI: 10.1042/BJ20080102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adaptor protein Lnk associates with Tyr(568) in c-Kit.PMID 18588518Read ↗

The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Semantic proximity Read ↗

Expression of the adaptor protein Lnk in leukemia cells.Semantic proximity Read ↗

Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms.Semantic proximity Read ↗

Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK.Semantic proximity Read ↗

Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders.Semantic proximity Read ↗

Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.Semantic proximity Read ↗

LNK mutations and myeloproliferative disorders.Semantic proximity Read ↗

Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2.Semantic proximity Read ↗

Lnk constrains myeloproliferative diseases in mice.Semantic proximity Read ↗

Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways.Semantic proximity Read ↗

Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617FSemantic proximity Read ↗

SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.