Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis.

Gastroenterology - 1 Feb 2005

Ho Gwo-Tzer, Nimmo Elaine R, Tenesa Albert, Fennell Janice, Drummond Hazel, Mowat Craig, Arnott Ian D, Satsangi Jack

Abstract excerpt

BACKGROUND AND AIMS: The MDR1 gene encodes P-glycoprotein 170, an efflux transporter that is highly expressed in intestinal epithelial cells. The MDR1 exonic single nucleotide polymorphisms (SNPs) C3435T and G2677T have been shown to correlate with activity/expression of P-glycoprotein 170. METHODS: This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Age of Onset

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colitis, Ulcerative

Share to Crohn Disease

Share to Genes, MDR

Share to Genetic Variation

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 15685540
DOI: 10.1053/j.gastro.2004.11.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis.PMID 15685540Read ↗

Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: a case-control and meta-analysis study.Semantic proximity Read ↗

Multidrug resistance 1 gene polymorphism and susceptibility to inflammatory bowel disease.Semantic proximity Read ↗

ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach.Semantic proximity Read ↗

Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.Semantic proximity Read ↗

Genetic analysis of MDR1 and inflammatory bowel disease reveals protective effect of heterozygous variants for ulcerative colitis.Semantic proximity Read ↗

MDR1 gene polymorphisms are associated with ulcerative colitis in a cohort of Serbian patients with inflammatory bowel disease.Semantic proximity Read ↗

Associations between ABCB1/MDR1 gene polymorphisms and Crohn's disease: a gene-wide study in a pediatric population.Semantic proximity Read ↗

MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients.Semantic proximity Read ↗

MDR1 gene: susceptibility in Spanish Crohn's disease and ulcerative colitis patients.Semantic proximity Read ↗

Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease.Semantic proximity Read ↗

Associations between common variants in the MDR1 (ABCB1) gene and ulcerative colitis among North Indians.Semantic proximity Read ↗

Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.