Article
MDR1 gene: susceptibility in Spanish Crohn's disease and ulcerative colitis patients.
Inflammatory bowel diseases - 1 Jan 2006
Urcelay Elena, Mendoza Juan L, Martín M Carmen, Mas Ana, Martínez Alfonso, Taxonera Carlos, Fernandez-Arquero Miguel, Díaz-Rubio Manuel, de la Concha Emilio G
Abstract excerpt
BACKGROUND: The multidrug resistance MDR1 gene codes for a membrane transporter associated with inflammatory bowel disease. The polymorphism Ala893Ser/Thr (G2677T/A) previously showed significant association with Crohn's disease (CD) and the Ile1145Ile (C3435T) with ulcerative colitis (UC). We studied the association of both polymorphisms in an independent population to reveal the impact of the MDR1 gene on...
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