Article
Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: a case-control and meta-analysis study.
Inflammatory bowel diseases - 1 Apr 2006
Onnie Clive M, Fisher Sheila A, Pattni Reenal, Sanderson Jeremy, Forbes Alastair, Lewis Cathryn M, Mathew Christopher G
Abstract excerpt
BACKGROUND: Allelic variants of the ATP-binding cassette, subfamily B member 1 (ABCB1), also known as the multidrug resistance gene (MDR1) that encodes the membrane-bound efflux transporter P-glycoprotein 170 (PGP-170), have been associated with inflammatory bowel disease but with conflicting results. METHODS: The present study examined the association of ABCB1 C3435T and G2677T/A in a large British case-control...
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