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Article

Associations between ABCB1/MDR1 gene polymorphisms and Crohn's disease: a gene-wide study in a pediatric population.

Inflammatory bowel diseases - 1 Jun 2009

Krupoves Alfreda, Seidman Ernest G, Mack David, Israel David, Morgan Kenneth, Lambrette Philippe, Costea Irina, Deslandres Colette, Grimard Guy, Law Liliane, Levy Emile, Amre Devendra K

Abstract excerpt

BACKGROUND: Functional studies support the involvement of the MDR1 gene in the pathways leading to Crohn's disease (CD). Two common single nucleotide polymorphisms (SNPs), C3435T and G2677T/A, thought to alter the function of the corresponding P-glycoprotein, have shown inconsistent associations with CD. We investigated whether DNA variants in the MDR1 gene were associated with susceptibility for CD and specific...

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Identifiers

PMID: 19107781
DOI: 10.1002/ibd.20849

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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