Article
Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development.
International immunology - 1 Mar 2005
O'Keeffe Meredith, Brodnicki Thomas C, Fancke Ben, Vremec David, Morahan Grant, Maraskovsky Eugene, Steptoe Raymond, Harrison Leonard C, Shortman Ken
Abstract excerpt
A dendritic cell (DC) imbalance with a marked deficiency in CD4- 8+ DC occurs in non-obese diabetic (NOD) mice, a model of human autoimmune diabetes mellitus. Using a NOD congenic mouse strain, we find that this CD4- 8+ DC deficiency is associated with a gene segment on chromosome 4, which also encompasses non-MHC diabetes susceptibility loci. Treatment of NOD mice with fms-like tyrosine kinase 3 ligand (FL)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.