Article
1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2014
Ferreira Gabriela B, Gysemans Conny A, Demengeot Jocelyne, da Cunha João Paulo M C M, Vanherwegen An-Sofie, Overbergh Lut, Van Belle Tom L, Pauwels Femke, Verstuyf Annemieke, Korf Hannelie, Mathieu Chantal
Abstract excerpt
The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is able to promote the generation of tolerogenic mature dendritic cells (mDCs) with an impaired ability to activate autoreactive T cells. These cells could represent a reliable tool for the promotion or restoration of Ag-specific tolerance through vaccination strategies, for example in type 1 diabetes patients. However, successful...
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