Article
Genetic control of anti-Sm autoantibody production in NOD congenic mice narrowed to the Idd9.3 region.
Immunogenetics - 1 Feb 2006
Irie Junichiro, Wu Yuehong, Sass David A, Ridgway William M
Abstract excerpt
Anti-Smith (anti-Sm) autoantibodies are directed to proteins in the small-nuclear ribonucleoprotein (snRNP) family and are considered specific for systemic lupus erythematosus (SLE) in both humans and mice. We previously established that NOD.c3c4 mice, carrying B6 and B10 congenic segments from chromosomes 3 to 4 on an nonobese diabetic (NOD) background, and NOD.Idd9R28 mice, carrying a B10 segment on c4 alone,...
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