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Genetic and functional analysis of the Nkt1 locus using congenic NOD mice: improved Valpha14-NKT cell performance but failure to protect against type 1 diabetes.

Diabetes - 1 Apr 2006

Rocha-Campos Ana-Claudia, Melki Rahma, Zhu Ren, Deruytter Nathalie, Damotte Diane, Dy Michel, Herbelin André, Garchon Henri-Jean

Abstract excerpt

Defective invariant natural killer T-cells (iNKT cells) have been implicated in the etiology of type 1 diabetes in nonobese diabetic (NOD) mice. In a genome scan of a cross between NOD and C57BL/6 mice, the most significant locus controlling the number of iNKT cells, referred to as Nkt1, was recently mapped to distal chromosome 1. Here, using congenic mice for this chromosomal segment, we definitively demonstrate...

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PMID: 16567543
DOI: 10.2337/diabetes.55.04.06.db05-0908

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