Article
Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.
Science (New York, N.Y.) - 30 Apr 1993
Prins J B, Todd J A, Rodrigues N R, Ghosh S, Hogarth P M, Wicker L S, Gaffney E, Podolin P L, Fischer P A, Sirotina A
Abstract excerpt
A congenic, non-obese diabetic (NOD) mouse strain that contains a segment of chromosome 3 from the diabetes-resistant mouse strain B6.PL-Thy-1a was less susceptible to diabetes than NOD mice. A fully penetrant immunological defect also mapped to this segment, which encodes the high-affinity Fc receptor for immunoglobulin G (IgG), Fc gamma RI. The NOD Fcgr1 allele, which results in a deletion of the cytoplasmic...
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