Article
Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2005
Litherland Sally A, Grebe Kristie M, Belkin Nicole S, Paek Edward, Elf Jessica, Atkinson Mark, Morel Laurence, Clare-Salzler Michael J, McDuffie Marcia
Abstract excerpt
Unstimulated monocytes of at-risk/type 1 diabetic humans and macrophages of the NOD mouse have markedly elevated autocrine GM-CSF production and persistent STAT5 phosphorylation. We analyzed the relationship between GM-CSF production and persistent STAT5 phosphorylation in NOD macrophages using reciprocal congenic mouse strains containing either diabetes-susceptible NOD (B6.NODC11), or diabetes-resistant C57L...
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