Article
Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset.
Nature communications - 25 Sept 2023
Zhang Jing, Zou Yuan, Chen Longmin, Sun Fei, Xu Qianqian, Zhou Qing, Wang Yi, Luo Xi, Wang Na, Li Yang, Zhang Shu, Xiong Fei, Yang Ping, Liu Shiwei, Yang Tao, Weng Jianping, Eizirik Décio L, Yan Jinhua, Zhou Zhiguang, Wang Cong-Yi
Abstract excerpt
The regulation of autoimmunity against pancreatic islet β cells for type 1 diabetes (T1D) onset is still unclear. NOD/ShiLtJ (NOD) mice are prone to the onset of autoimmune diabetes, but its congenic strain, ALR/Lt (ALR), is not. Here we show that dendritic cells (DC) in ALR mice have impaired migratory and T-cell priming capability. Genomic comparative analysis maps a 33-bp deletion in the ALR Myosin IXb (Myo9b)...
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