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Article

Effects of peroxynitrite dose and dose rate on DNA damage and mutation in the supF shuttle vector.

Chemical research in toxicology - 1 Jan 2005

Kim Min Young, Dong Min, Dedon Peter C, Wogan Gerald N

Abstract excerpt

Peroxynitrite (ONOO-) induces oxidative and nitrosative DNA damage, and previous studies by our group have shown that it is strongly mutagenic in the supF shuttle vector pSP189 replicated in Escherichia coli MBL50 cells. In those experiments, however, the pSP189 plasmid was exposed under unphysiological conditions to large single bolus doses of ONOO-, which limits extrapolation of the data to in vivo pathological...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15651852
DOI: 10.1021/tx049777m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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