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Article

Peroxynitrite-induced DNA damage in the supF gene: correlation with the mutational spectrum.

Mutation research - 14 Feb 2000

Tretyakova N Y, Burney S, Pamir B, Wishnok J S, Dedon P C, Wogan G N, Tannenbaum S R

Abstract excerpt

Tissue inflammation and chronic infection lead to the overproduction of nitric oxide and superoxide. These two species rapidly combine to yield peroxynitrite (ONOO(-)), a powerful oxidizing and nitrating agent that is thought be involved in both cell death and an increased cancer risk observed for inflamed tissues. ONOO(-) has been shown to induce single-strand breaks and base damage in DNA and is mutagenic in...

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Identifiers

PMID: 10751613
DOI: 10.1016/s0027-5107(99)00221-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Peroxynitrite-induced DNA damage in the supF gene: correlation with the mutational spectrum.PMID 10751613Read ↗

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