Genotoxicity and mutagenicity of the alpha, beta-unsaturated carbonyl compound crotonaldehyde (butenal) on a plasmid shuttle vector.

doi:10.1016/s0921-8777(97)00069-4

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Article

Genotoxicity and mutagenicity of the alpha, beta-unsaturated carbonyl compound crotonaldehyde (butenal) on a plasmid shuttle vector.

Mutation research - 1 Mar 1998

Czerny C, Eder E, Rünger T M

Abstract excerpt

Crotonaldehyde is an alpha,beta-unsaturated carbonyl compound and an important environmental and industrial toxic substance. Its mutagenic and carcinogenic properties are related to its reactivity to DNA, where it forms different guanine adducts. In order to study the mutagenic consequences of this agent in intact human cells, we treated the shuttle vector plasmid pZ189 with different doses of crotonaldehyde at...

Topics

Aldehydes
Base Sequence
Cell Line, Transformed
DNA
DNA Damage
DNA Fragmentation
DNA Mutational Analysis
Dose-Response Relationship, Drug
Genes, Bacterial
Genes, Suppressor
Genetic Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Mutagenesis

Mutagenicity Tests

Mutation

Plasmids

RNA, Transfer

Source

Open in PubMed

Identifiers

PMID: 9637241
DOI: 10.1016/s0921-8777(97)00069-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9637241-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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