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Article

Genotoxicity and mutagenicity of the alpha, beta-unsaturated carbonyl compound crotonaldehyde (butenal) on a plasmid shuttle vector.

Mutation research - 1 Mar 1998

Czerny C, Eder E, Rünger T M

Abstract excerpt

Crotonaldehyde is an alpha,beta-unsaturated carbonyl compound and an important environmental and industrial toxic substance. Its mutagenic and carcinogenic properties are related to its reactivity to DNA, where it forms different guanine adducts. In order to study the mutagenic consequences of this agent in intact human cells, we treated the shuttle vector plasmid pZ189 with different doses of crotonaldehyde at...

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PMID: 9637241
DOI: 10.1016/s0921-8777(97)00069-4

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