Mutagenic activity of ambient oxygen and mitomycin C in Fanconi's anaemia cells.

doi:10.1093/mutage/12.2.69

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Article

Mutagenic activity of ambient oxygen and mitomycin C in Fanconi's anaemia cells.

Mutagenesis - 1 Mar 1997

Liebetrau W, Rünger T M, Mehling B E, Poot M, Hoehn H

Abstract excerpt

Cellular evidence suggests that Fanconi's anaemia (FA) might be a condition of increased oxygen sensitivity. In order to test this hypothesis, a common shuttle vector assay with the plasmid pZ189 was utilized. We transfected intact, circular plasmid into FA and control lymphoblast and fibroblast...

Topics

Base Sequence
Cells, Cultured
DNA Mutational Analysis
Fanconi Anemia
Humans
Mitomycin
Molecular Sequence Data
Mutation
Nucleic Acid Synthesis Inhibitors
Oxygen
Sequence Deletion
Transfection

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